How can a filibuster be broken? What do the changes for breaking a filibuster mean for trying to pass a bill?

when 60% vote to end debate, of course a bill unpopular enough to support a filibuster should die. Like the huge spend bills being pushed by Obama as part of a so called stimulus package.How can a filibuster be broken? What do the changes for breaking a filibuster mean for trying to pass a bill?
It takes a super majority or 60 Senators to end debate.